Intravenous Trypsin

Intravenous trypsin in experimental myocardial infarction.

The possibility of using intravenous proteolytic agents in the treatment of acute myocardial infarction lias been studied. The coronary arteries of closed-chest dogs were embolized with small repetitive doses of fibrin clots until definite electrocardiographic evidence of myocardial injury which persisted for at least two hours was observed. The treated animals were given up to six intravenous ...

The effect of intravenous injection of trypsin inhibitor on the coagulation of blood.

Trypsin inhibitor.’ A crude preparation was obtained by the method described previously.2 Dialysis of the final preparation for twenty-four hours against saline in the ice-box was found to be necessary for the removal of a toxic factor present in the undialyzed material. Without dialysis, small amounts (o. -z cc.) of the material regularly killed the s-pound rabbits in a very short time (30 tO ...

The effect of intravenous trypsin administration on the electrocardiogram of the rabbit.

Calorimetry of some trypsin-trypsin inhibitor reactions.

The heats of reaction of trypsin with soybean (Kunitz), ovomucoid, and lima bean inhibitors have been measured at pH 5.0 and 10’ and 25”. All the reactions were endothermic, with AH ranging from 8.6 Cal per mole for the lima bean inhibitor to 15.3 Cal per mole for the soybean inhibitor. Equilibrium constants for the association were calculated from the dependence of residual tryptic activity up...

Trypsin Revisited

From the ‡European Molecular Biology Laboratory (EMBL) Hamburg c/o DESY, D-22607 Hamburg, Germany, the **Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61–704 Poznan, Poland and Institute of Biochemistry and Molecular Biology, University Hospital, Hamburg-Eppendorf, c⁄o DESY, 22603 Hamburg, Germany, the ¶Laboratoire de Cristallographie et Modelisation des Matériaux Mineraux et B...